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chapter one Introduction: The Psychedelic Renaissance Continues Michael Winkelman and Ben Sessa Following the groundbreaking success of Psychedelic Medicine: Volumes 1 and 2 (Winkelman & Roberts, 2007), it is with great pleasure that we bring you Advances in Psychedelic Medicine: State-of-the-Art Therapeutic Applications. The words “psychedelic renaissance” have been used with increasing frequency in recent years—with good reason. When Psychedelic Medicine was released a decade ago, we were at the beginning of the new profes- sional wave of interest in psychedelics heralding the “psychedelic renais- sance” (Sessa, 2012/2017). The opening of research in the first decade of the 21st century made possible an evaluation of the therapeutic potential of psychedelics, and we are now in the midst of a new understanding of the potentials of psychedelics. The sheer volume of published papers on psychedelics reviewed in the chapters here, and the growing number of research institutions with active psychedelic research programs, attest to this ongoing revolution. Across the globe major neuroscientific and medical institutions are now running psychedelic research programs, including Imperial College London, Johns Hopkins University, New York University, University Col- lege London, Oxford University, Harvard, University of California Los Angeles, Cambridge University, Yale University, the Maudsley Institute,